While in San Francisco this past weekend, my friend and I decided to add a few days to the trip to head up to Napa Valley for some relaxation.  We had two days open specifically for wine tasting adventures, so I did some research on the internet and narrowed available selections down to a realistic 3-5 wineries per day.  Any more, and I feel like it diminishes the tasting experience at each stop because maybe you're tired or maybe you reach your wine limit for the day.  Next, I took the list and organized it by location in order to minimize driving time.  Here are my results, followed by hotel and restaurant experiences for you to consider when planning your own trip to the Napa Valley...
My Two Day Wine Tasting Itinerary for the Napa Valley:

 Day 1 - Silverado Trail

 1. Van der Heyden Vineyards (4057 Silverado Trail, reservation not required)
Tasting: $10 for 4-5 current wines
Van der Heyden is a small, family owned winery along the Silverado Trail that produces 33 different wines and is famous for their late harvest cabernet.  The tasting experience is very no frills, in fact my friend called it the "hillbilly" winery because of the parked RV and inflatable pool by the tasting "shack." Out of the five wines we tasted, the most interesting one was the 2002 Semillon Late Harvest Botrytis.  This wine is made using select grapes that have been affected by the botrytis fungus.  The taste is a sweet wine with strong butterscotch flavor.  I think it would go really great after a Thanksgiving meal, maybe even with a slice of pecan pie.  The price tag is a little steep, though, because a large majority of the crop is spoiled by the fungus, and there is a lot of labor involved in inspecting the grapes multiple times per week, then manually picking the ones that are positively changed by the fungus.  You should save this wine only for a dinner party where you really like the friends invited.  

 2. Regusci Winery (5584 Silverado Trail, reservation not required)
Tasting: $25
The term "Ghost Winery" was given to the few remaining early Napa Valley wineries that were in existence between 1860 and 1900. Very few of these Ghost Wineries remain after the phylloxera infestation of the 1890's destroyed the vines, then prohibition and the depression made it near impossible to turn a profit producing wine.  In addition, even fewer of these remaining Ghost Wineries are in as pristine condition as the building now used by the Regusci family, formerly the T.L Grigsby-Occidental Winery.

Built in 1878, the winery is reminiscent of Tuscany's stone façade vineyard buildings. This three story winery was built to promote a gravity-aided winemaking process.  The top floor was used for crushing, then the juice was sent to the second floor for settling and fermentation, and was put into barrels for storage and aging on the bottom floor.  During prohibition, the winery still produced wine, for religious purposes and some extra for bootlegging, but was primarily used as a dairy and storage for non-grape crops.  In 1932, the winery and associated acres were purchased by Gaetano Regusci and has been a family run operation since, diverting all estate activities towards winemaking in 1995, producing its first vintage of Stags Leap District wines in 1996 and estate wines in 1998.

3. T Vine (at Regusci Winery)
Complimentary tasting, may need to reserve in advance

T-Vine was founded in 1992 by winemaker Greg Brown, and is now a partnershop with friends and winemakers, including Jim Regusci.  T-Vine has a tradition of using less common grapes from old vines in the Napa Valley - Grenache, Zinfandel and Petite Sirah. This tasting was a surprise because we didn't know that they were pouring just upstairs from the Regusci tasting room.  They were kind enough to take us without an appointment, and we not only got to taste some great wines but got to see the top floor of the original Ghost Winery that now contains barrels of aging wine as well as the private overflow cellar of Jim Regusci.  

T-Vine is also producing a second label that includes wines with outrageous names, like F-Bomb and G-Spot.  We weren't provided with tastings of them, but I had to buy some bottles on the name alone.  And if they are of the same quality as the other wines, I think I will have a great experience when I open them.

4. Robert Sinsky Vineyards (6320 Silverado Trail, reservation not required)
Tasting: $25 and comes with a selection of food bites to nibble)
While Robert Sinskey is recognized as one of Napa's organic producers of wine, and will soon earn the biodynamic designation as well, they distinguish their tasting experience with a plate full of small bites meant to be paired with the wine.  Overall, I didn't think that their wines really stood out in taste, but nonetheless enjoyed the atmosphere and the friendly staff.

5. Silverado Vineyards (6121 Silverado Trail, reservations not required for current release)
Tasting: $15, try to be there around sunset for the best views from the terrace
While the wine was mediocre, the view was fantastic.  There was less interaction with the pourers in the tasting room because of the allure of just sitting out on the terrace.  They really should consider just doing a sit down experience outside because not a soul was inside.  

Day 2 - Calistoga to Oakville

Spring Mountain Winery (2805 Spring Mountain Road, St. Helena, reservations required for all tours and tastings)
Tasting:  $25 for classic tasting served by reservation only at 10am and 2pm
Spring Mountain Vineyard is a Napa Valley estate that covers 850 acres on the eastern slopes of Spring Mountain in St. Helena, which allows them to produce many varietals of grapes because of the various soil types and microclimates.  It is the only vineyard in Napa to plant some of its vines in the vertical roman gobelet method to allow for denser planting along the hills and tree groves.  The winery primarily grows the Bordeaux grape varieties, and we got to taste the sauvignon blanc, pinot noir, cabernet sauvignon, and the estate blend, Elivette.  These tasting sessions are limited to only a few people, allowing for a more intimate experience.  With good weather, the tastings are done on the outdoor bar overlooking a sample vineyard planted in the goblet style - an absolutely beautiful way to taste wine.

 Sterling Vineyards (1111 Dunaweal Lane, Calistoga, reservation not required)
Tasting: $25 for gondola ride to tasting room and tasting, discounts available when booked in advance or with coupon
 
Once you arrive in the visitor parking lot, there's a ticket booth where you purchase your tasting experience that also includes a gondola ride to the winery - a white spanish mission-looking building atop the hill.  The tasting experience is a progressive, self-guided, sip-and-walk structure where you follow the signs to various areas of the winery.  The property is very commercial, and the tour is complete with extensive signage to explain the winemaking processes.  We stopped to watch the flatbed trucks dump large vats of cabernet grapes into the de-steming machine - visually demonstrating the volume of wine produced here compared to a boutique winery.  The tour's 4th stop is on the large, southward facing terrace that overlooks the vineyards of Calistoga.  Finally, you end in the winery gift shop and wine store.  My favorite part of the visit was the tree-lined drive from the gate to the parking lot that was absolutely gorgeous with fall's turning trees.  Some of the vines along the road were also turing brilliant shades of red, orange, and yellow.
V. Sattui Winery (1111 White Lane at Hwy. 29, St. Helena, reservation not required)
Tasting: $10, coupons frequently available 
We didn't actually end up doing a wine tasting at V. Sattui.  This is a popular breaking point for northern Napa Valley wine tours because the winery not only sells everything you need for a picnic - meats, cheeses, pre-made sandwiches, prepackaged disposable tableware, etc. - but the wine (should you choose to drink some) to complement your mid-day meal. They have other beverages for sale as well.  Once everything is purchased, you can find a space on one of the many picnic tables below the trees to enjoy your yummy food.

Frogs Leap Vineyards (8815 Conn Creek Rd., Rutherford, tour reservations required)
Tasting: $20 for a tour of the winery while tasting along the way
This was by far my favorite stop.  We opted to do the reserved tour experience because I had read it was one not to miss. Frogs Leap is a certified organic winery that was established in 1980.  On the property, they also grow seasonal fruits and vegetables that they sell in local farmer's markets and to local restaurants.  The tour starts amongst the vines, where you learn what it takes to be organic, including the planting of vegetables that naturally infuse the soil with the nitrogen the vines love, such as fava beans and mustard.  You also learn about dry farming - their vines receive no irrigation at all because it has been determined that the natural rainfall is more than enough, even in a drought, to adequately irrigate these vines who have much deeper roots than the more commercial vines.  In comparison, vines that receive fertilizer enhanced irrigation tend to grow root balls that are shallower and more susceptible to disease and insects, and often these irrigated fields need to be replanted much more frequently than the heartier, organic-bred vineyard.
Next, the tour heads over to the red barn, part of the original property that had two red barns used for the winemaking processes.  One of the original barns burned down and has been replaced with a brown barn that now serves as the barrel aging storage and bottling facility.  The red barn contains all of the fermentation stainless steel vats.  
One of my favorite parts of the property was the building that contained the tasting room and the winery's business operations. It looked like it was featured in a cover article for Architectural Digest.  The building was supposedly modeled on an Australian farmhouse layout, with a living room in the center of the first floor, surrounded by the functional rooms like the dining room, kitchen, and study.  The upper floor is ideal for bedrooms, but is being used now for an open workspace.  I loved the design details, like the light brownish grey walls with a darker grey used for the trim that was also repeated on the exterior.  And the wrap-around porch overlooking the vineyard and the garden was to die for!

Hotel:
We opted to stay in the quaint town of Yountville, just north of Napa.  The whole town couldn't be more than a mile long, and the main street, Washington Street, contains some of the best restaurants and hotels in the region.  We chose to stay at the Villagio Inn and Spa on the southside of town.  They had a complimentary breakfast every morning with not only a made-to-order omelet bar but bottomless mimosas!  The spa offered a variety of services, and you were even allowed to use the facilities (sauna, steam room, hot tub, etc.) without a spa appointment.  The rooms were large and clean, and the location was perfect for a short walk to delicious food after a long day of touring.

Dining in Yountville:

Redd Wood - This restaurant is primarily a gourmet pizzeria with interesting flavor combinations, very casual atmosphere, and friendly service.  I ordered the special appetizer - tomato cream soup with cheese panini (a.k.a. grilled cheese) that was absolutely delicious.  For the main course, I got the pizza with ricotta, white corn, pecorino, red onion, bacon, chili flakes, and basil, then added a fried egg on top for extra flavor.  And for dessert, that I had to take back to the hotel because I was stuffed, I had a huckleberry cheesecake.

Bouchon Bistro by Chef Thomas Keller - Better known for his exclusive establishment up the street, French Laundry, Bouchon is a restaurant serving french bistro cuisine.  The food we ordered, off of the great paper napkin wraps that doubled as menus, was amazing. Each leaf of my Salade de Cresson et d'Endives au Roquefort, Pommes et Noix was individually stacked to create a visually stunning structure of greens, reds, and yellows.  Then my brown butter, pan-seared gnocchi was the perfect main dish.  My friend's gratin was an absolute cheese beauty that went very well with some of the best duck confit she's ever tasted.  I wasn't very impressed with my fall spice creme brulée for dessert, though.  Reservations can be made on Open Table.

Bottega by Chef Michael Chiarello - I was very disappointed by my dining experience at Bottega, especially after hitting it out of the park the previous two nights.  The restaurant, itself, was larger than the others and the service seemed a lot more rushed.  As for the food, my friend enjoyed her smoked and braised short ribs, which are supposedly the most popular main dish on the menu.  I, on the other hand, ordered the pancetta wrapped salmon that came very undercooked on the first try, and slightly more cooked (medium rare) on the second try after asking for it to be prepared medium-well to well done.  Finally, I got something edible on my third piece of salmon.  After all that, I wasn't really amazed by the taste combination.  The pancetta served to create a sweet crust on the fish, kind of like a caramelized teriyaki.  For dessert, we ordered the chocolate lava cakes with hazelnut creme and candied hazelnuts.  They were fabulous!  The manager felt bad about the fish not being cooked well and took that dish and the two desserts off the menu.  I'm not sure I would go back, though, if they can't even cook a piece of salmon.  Perhaps I should have selected the homemade pasta instead.